The Dodgers’ starting pitcher and designated hitter exited ahead of the seventh inning after allowing three earned runs on seven hits, with nine strikeouts and two walks on a season-high 110 pitches.
He went 0-for-3 at the plate before he was replaced by Miguel Rojas.
After the game, Ohtani told reporters that he was concerned about his bicep after his last at-bat and exited as a precaution.
On the season, the two-way threat has a .288/.403/.524 slash line with 18 home runs and 50 RBI in 309 at-bats. On the mound, Ohtani has a 1.79 ERA with 95 strikeouts and 26 walks.
The Dodgers are in action again on Saturday.