The Toronto Blue Jays right-hander was three outs from the second no-hitter in franchise history against the San Francisco Giants before a Heilot Ramos single to centre in the bottom of the ninth ended his bid.
Dave Stieb will remain as the only Blue Jay with a no-hitter, accomplishing the feat in 1990 in Cleveland.
Cease exited the game with a final line of one hit allowed, three walks, zero earned runs and 11 strikeouts over eight innings of work and a career-high 118 pitches.
He received a standing ovation as he left the field before the Blue Jays finished off an 10-0 win.
Despite losing his no-no bid, baseball fans took to social media to applaud Cease’s effort. Here are some of the best reactions.