Rodríguez was hit in the back of the head by a throw from Los Angeles Angels first baseman Nolan Schanuel and eventually entered concussion protocol.
The Mariners recalled Miles Mastrobuoni from triple-A Tacoma to take Rodríguez’s spot on the active roster.
Mastrobuoni has played in eight games with Seattle this season, collecting five hits in 27 plate appearances.
Rodríguez, 25, has once again been a solid producer at the top of Seattle’s lineup. Over 87 games this season, he has a .747 OPS with 14 home runs and 12 stolen bases.
The Blue Jays and Mariners open their three-game series at 10 p.m. ET / 7 p.m. PT on Friday on Sportsnet and Sportsnet+.